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美國(guó)Invitrogen CellzDirect    
全球生命技術(shù)行業(yè)的領(lǐng)導(dǎo)者Invitrogen(英杰生命技術(shù)有限公司)新近成功收購(gòu)了CellzDirect Inc (CellzDirect公司)。這是繼去年成功收購(gòu)Cascade Biologics之后，Invitrogen在細(xì)胞生物學(xué)領(lǐng)域的又一個(gè)重大舉措。

CellzDirect是一家私有的生物技術(shù)公司，成立于2001年，總部位于美國(guó)北卡羅林那州的德罕市(Durham, North Carolina, USA)，向生物公司和制藥公司提供高品質(zhì)的細(xì)胞產(chǎn)品和服務(wù)，主要關(guān)注的領(lǐng)域包括藥物代謝，藥物交互作用和藥物轉(zhuǎn)運(yùn)體等。在CellzDirect的支持下，科學(xué)家們可以更好的開(kāi)展科研工作，加速安全、高效藥品的研發(fā)。

Hepatocyte(人肝細(xì)胞)是CellzDirect的主要產(chǎn)品之一，它是新藥檢測(cè)的重要工具。原代hepatocyte能夠預(yù)測(cè)各組分在肝中對(duì)酶代謝的影響，是現(xiàn)今該領(lǐng)域最受關(guān)注的工具，也是FDA要求使用的檢測(cè)方法，它可以大大降低臨床試驗(yàn)失敗造成的巨大損失。因此，CellzDirect的產(chǎn)品主要用于生物和制藥公司的研發(fā)。原代hepatocyte也可用于生物醫(yī)療，用來(lái)研究肝的疾病，和細(xì)胞功能的下游價(jià)值，因?yàn)轶w內(nèi)的每一個(gè)系統(tǒng)都與肝密切相關(guān)。

CellzDirect自成立以來(lái)，以其獨(dú)特而又健康的組織來(lái)源網(wǎng)絡(luò)，高品質(zhì)hepatocyte的制備，雄厚的檢測(cè)平臺(tái)，和出色的結(jié)果分析，取得了飛速的發(fā)展，平均每年以70%的速度上升。由于CellzDirect在科學(xué)界的領(lǐng)導(dǎo)地位，與科學(xué)和工業(yè)領(lǐng)域權(quán)威的磋商，和持續(xù)不斷的與醫(yī)療團(tuán)體、制定規(guī)章的機(jī)構(gòu)和其用戶的溝通，使其在原代細(xì)胞的供應(yīng)者中一枝獨(dú)秀。

CellzDirect的加盟，無(wú)疑會(huì)大大推進(jìn)Invitrogen在生命技術(shù)行業(yè)，特別是在細(xì)胞生物學(xué)領(lǐng)域的領(lǐng)導(dǎo)地位。對(duì)于原旗下的GIBCO?品牌——這一全球細(xì)胞培養(yǎng)領(lǐng)域的泰斗，CellzDirect是其非常有益的補(bǔ)充和促進(jìn)。CellzDirect高價(jià)值的產(chǎn)品和服務(wù)，進(jìn)一步將Invitrogen細(xì)胞系統(tǒng)的產(chǎn)品線完善和升值，至此，Invitrogen已擁有了完整的、高品質(zhì)的細(xì)胞系統(tǒng)的產(chǎn)品線，包括原代細(xì)胞，培養(yǎng)基，三維基質(zhì)，生長(zhǎng)因子，等等。
 CellzDirect is building a preeminent cell-based bioscience company that provides innovative ADME products and services to expedite the development of safe, effective drugs.

Our Company

Now part of the Invitrogen family, CellzDirect provides high-quality in vitro ADME cell products and contract laboratory and consulting services focused primarily on drug metabolism and transport. Our clients include leaders in the pharmaceutical, biotech, academic, chemical and consumer products fields as well as government agencies. With CellzDirect’s support, scientists conduct research that accelerates the discovery of safe and effective drugs.

CellzDirect offers a complete line of fresh and cryopreserved hepatocytes and liver subcellular fractions, and transporters derived from a variety of species, including human, non-human primate, dog, rat and mouse. Members of our scientific staff have dedicated up to 20 years on research to optimize the isolation conditions and culture techniques by species.

Our service offerings include drug-drug interaction studies, drug metabolism studies and hepatotoxicity studies, such as enzyme induction and inhibition, reaction phenotyping, metabolite stability and profiling, and P-gp assays. These studies can be conducted in GLP (Good Laboratory Practices) or non-GLP formats, and study data can be presented for FDA submissions.