日本RIBM HS-AFM超高速視頻***原子力顯微鏡
超高速視頻***原子力顯微鏡(Sample-Scanning High-Speed Atomic Force Microscope ,HS-AFM SS-NEX)是由日本 Kanazawa 大學(xué) Prof. Ando 教授團(tuán)隊(duì)歷經(jīng)數(shù)十年研發(fā)而成的,也是世界上***臺(tái)可以達(dá)到視頻***成像的商業(yè)化原子力顯微鏡。
![](http://www.lxyee.net/Upload/images/%E6%97%A5%E6%9C%ACRIBM%20HS-AFM%E8%B6%85%E9%AB%98%E9%80%9F%E8%A7%86%E9%A2%91%E7%BA%A7%E5%8E%9F%E5%AD%90%E5%8A%9B%E6%98%BE%E5%BE%AE%E9%95%9C(1).png)
相較于目前市場(chǎng)上的原子力顯微鏡成像設(shè)備,HS-AFM突破了 “掃描成像速慢”的限制,掃描速度可達(dá) 20 frame/s,并且有 4 種掃描臺(tái)可供選擇。樣品無(wú)需特殊固定染色,不影響生物分子的活性,尤其適用于生物大分子互作動(dòng)態(tài)觀測(cè)。液體環(huán)境下直接檢測(cè),超快速動(dòng)態(tài)成像,分辨率為納米水平。探針小,適用于生物樣品;懸臂探針共振頻率高,彈簧系數(shù)小,避免了對(duì)生物樣品等的損傷。懸臂探針可自動(dòng)漂移校準(zhǔn),適用于長(zhǎng)時(shí)間觀測(cè)。采用動(dòng)態(tài)PID控制,高速掃描時(shí)仍可獲得清晰的圖像。XY軸分辨率2nm;Z軸分辨率0.5nm。
超高速視頻***原子力顯微鏡HS-AFM推出至今,全球已有80多位用戶,發(fā)表 SCI 文章 200 余篇,包括Science, Nature, Cell 等雜志。
HS-AFM超高速視頻***原子力顯微鏡應(yīng)用案例:
1.Video imaging of walking myosin V 實(shí)時(shí)觀察myosin V蛋白的運(yùn)動(dòng)
![](http://www.lxyee.net/Upload/images/%E5%9B%BE%201(22).png)
N. Kodera et al. Nature 468, 72 (2010). Kanazawa University
2.Real-space and real-time dynamics of CRISPR-Cas9 實(shí)時(shí)顯示CRISPR基因編輯
![](http://www.lxyee.net/Upload/images/%E5%9B%BE%202(19).png)
Mikihiro et al. Nature Communications, (2017). Kanazawa University
3. High-speed atomic force microscopy shows that annexin V stabilizes membranes on the second timescale
![](http://www.lxyee.net/Upload/images/%E5%9B%BE%203(17).png)
Miyagi A, et al. Nature Nanotechnology (2016)
4. IgGs are made for walking on bacterial and viral surfaces
![](http://www.lxyee.net/Upload/images/%E5%9B%BE%204(17).png)
J Preiner, et al. Nature Communications(2014)
5. Long-tip high-speed atomic force microscopy for nanometer-scale imaging in live cells
![](http://www.lxyee.net/Upload/images/%E5%9B%BE%205(10).png)
Mikihiro Shibata, et al. Scientific Reports(2015)
6. High-speed atomic force microscopy shows dynamic molecular processes in photoactivated bacteriorhodopsin
![](http://www.lxyee.net/Upload/images/%E5%9B%BE%206(6).png)
Shibata M, et al. Nature Nanotechnology (2010)
7. Tuning crystallization pathways through sequence engineering of biomimetic polymers
![](http://www.lxyee.net/Upload/images/%E5%9B%BE%207(6).png)
Xiang Ma, et al. Nature Materials (2017)
8. Lipid-bilayer-assisted two-dimensional self-assembly of DNA origami nanostructures
![](http://www.lxyee.net/Upload/images/%E5%9B%BE%208(7).png)
Yuki Suzuki, et al. Nature Communications(2015)
HS-AFM超高速視頻***原子力顯微鏡設(shè)備規(guī)格及配置參數(shù):
![](http://www.lxyee.net/Upload/images/%E5%9B%BE%209(4).png)
基本參數(shù):
![](http://www.lxyee.net/Upload/images/%E5%9B%BE%2010(2).png)
SS-NEX 型可選配置:
![](http://www.lxyee.net/Upload/images/%E5%9B%BE%2011(1).png)